Storage pool diseases illuminate platelet dense granule biogenesis

Platelet dense granules (DGs) are membrane bound compartments that store polyphosphate and small molecules such as ADP, ATP, Ca2+, and serotonin.The release of DG contents plays a central role in platelet aggregation to form a hemostatic plug.Accordingly, congenital deficiencies in the biogenesis of platelet DGs underlie human genetic disorders tha

read more

Biochemical and morphological changes in bone marrow mesenchymal stem cells induced by treatment of rats with p-Nonylphenol

Objective(s):In previous investigations, we have shown para-nonylphenol (p-NP) caused significant reduction of proliferation and Samsung GS20+ differentiation of rat bone marrow mesenchymal stem cells (MSCs) in vitro.In this study, we first treat the rats with p-NP, then carried out the biochemical and morphological studies on MSCs.Materials and Me

read more

Leaf Area Index Estimation Algorithm for GF-5 Hyperspectral Data Based on Different Feature Selection and Machine Learning Methods

Leaf area index (LAI) is an essential vegetation parameter that represents the light energy utilization and vegetation canopy structure.As the only in-operation hyperspectral satellite launched by China, GF-5 is potentially useful for accurate LAI estimation.However, there is no research focus on evaluating GF-5 data for LAI estimation.Hyperspectra

read more